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Published on: May 15, 2019
FTO promotes Bortezomib resistance via m6A-dependent destabilization of SOD2 expression in multiple myeloma
Chong Wang1, Lingling Li2, Mengya Li2
1Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. fccwangc@zzu.edu.cn.
Abstract:
Drug resistance is the main reason for the failure of Bortezomib (Bort) in the treatment of multiple myeloma (MM), which seriously affects the efficacy of Bort. Therefore, the exploration of Bort resistance to treat MM will be very beneficial. Thus, this study aims to study the function and mechanism of Fat mass and obesity associated (FTO) on the Bort resistance of MM. In the present study, we demonstrated that FTO promotes Bort resistance via m6A-dependent destabilization of SOD2 expression in MM. These findings may provide a substantial evidence for the Bort resistance in MM.
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