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Related Concept Videos

Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

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In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
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Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

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Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

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The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
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Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

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AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
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The Association Between Urinary Tract Infection and Overactive Bladder Treatment.

Kuang-Ming Liao1, Ka-Lok Lio2, Yu-Ju Chou3,4

  • 1Department of Internal Medicine, Chi Mei Medical Center, Chiali, Taiwan.

Frontiers in Pharmacology
|February 11, 2022
PubMed
Summary

Overactive bladder (OAB) medication adherence and type did not significantly impact urinary tract infection (UTI) risk. This study found no increased UTI risk with either anticholinergic medications or beta-3 agonists in OAB patients.

Keywords:
adherenceanti-muscarinic agentsmirabegronoveractive bladderpersistencepharmacoepidemiology

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Area of Science:

  • Urology
  • Pharmacology
  • Public Health

Background:

  • Overactive bladder (OAB) syndrome is characterized by urinary urgency, potentially with urge incontinence, without other identifiable causes.
  • Current OAB treatments include anti-muscarinic agents and beta-3 adrenoceptor agonists.
  • Previous research suggested a potential link between OAB treatments and increased urinary tract infection (UTI) risk.

Purpose of the Study:

  • To investigate the association between overactive bladder (OAB) medication adherence and the risk of developing urinary tract infections (UTIs).
  • To compare the UTI risk associated with different types of OAB medications, specifically anti-muscarinic agents and beta-3 adrenoceptor agonists.

Main Methods:

  • A nationwide, population-based, retrospective study utilizing data from the National Health Insurance Research Database (NHIRD).
  • Included patients diagnosed with OAB between January 1, 2014, and December 31, 2016.
  • Assessed medication adherence over 12 months and compared UTI risk using a multivariate Cox proportional-hazards model for anti-muscarinic agents and mirabegron.

Main Results:

  • The study included 21,869 patients diagnosed with overactive bladder (OAB).
  • No significant difference in UTI risk was observed based on the type of OAB medication used (anti-muscarinic agents vs. beta-3 agonists).
  • Medication adherence levels (high vs. low) did not influence the risk of developing a urinary tract infection (UTI).

Conclusions:

  • Overactive bladder (OAB) is a prevalent condition in Taiwan.
  • After a 12-month follow-up, neither the class of medication (anticholinergic vs. beta-3 agonist) nor the level of adherence affected the risk of urinary tract infections (UTIs).