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The Association Between Urinary Tract Infection and Overactive Bladder Treatment
Kuang-Ming Liao1, Ka-Lok Lio2, Yu-Ju Chou3,4
1Department of Internal Medicine, Chi Mei Medical Center, Chiali, Taiwan.
Frontiers in Pharmacology
|February 11, 2022
Summary
Overactive bladder (OAB) medication adherence and type did not significantly impact urinary tract infection (UTI) risk. This study found no increased UTI risk with either anticholinergic medications or beta-3 agonists in OAB patients.
Area of Science:
- Urology
- Pharmacology
- Public Health
Background:
- Overactive bladder (OAB) syndrome is characterized by urinary urgency, potentially with urge incontinence, without other identifiable causes.
- Current OAB treatments include anti-muscarinic agents and beta-3 adrenoceptor agonists.
- Previous research suggested a potential link between OAB treatments and increased urinary tract infection (UTI) risk.
Purpose of the Study:
- To investigate the association between overactive bladder (OAB) medication adherence and the risk of developing urinary tract infections (UTIs).
- To compare the UTI risk associated with different types of OAB medications, specifically anti-muscarinic agents and beta-3 adrenoceptor agonists.
Main Methods:
- A nationwide, population-based, retrospective study utilizing data from the National Health Insurance Research Database (NHIRD).
- Included patients diagnosed with OAB between January 1, 2014, and December 31, 2016.
- Assessed medication adherence over 12 months and compared UTI risk using a multivariate Cox proportional-hazards model for anti-muscarinic agents and mirabegron.
Main Results:
- The study included 21,869 patients diagnosed with overactive bladder (OAB).
- No significant difference in UTI risk was observed based on the type of OAB medication used (anti-muscarinic agents vs. beta-3 agonists).
- Medication adherence levels (high vs. low) did not influence the risk of developing a urinary tract infection (UTI).
Conclusions:
- Overactive bladder (OAB) is a prevalent condition in Taiwan.
- After a 12-month follow-up, neither the class of medication (anticholinergic vs. beta-3 agonist) nor the level of adherence affected the risk of urinary tract infections (UTIs).
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