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Glymphatic Dysfunction in Patients With End-Stage Renal Disease
Chang Min Heo1, Won Ho Lee1, Bong Soo Park1
1Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Frontiers in Neurology
|February 11, 2022
Summary
Patients with end-stage renal disease (ESRD) exhibit glymphatic dysfunction, as indicated by a lower diffusion tensor image analysis along the perivascular space (DTI-ALPS) index. This index may help assess glymphatic function in ESRD patients.
Area of Science:
- Neuroscience
- Nephrology
- Radiology
Background:
- End-stage renal disease (ESRD) is associated with neurological complications.
- Glymphatic system dysfunction is implicated in various neurological disorders.
Purpose of the Study:
- To compare glymphatic function between ESRD patients and healthy controls.
- To analyze the correlation between glymphatic function and clinical characteristics in ESRD patients.
Main Methods:
- Prospective enrollment of 49 neurologically asymptomatic ESRD patients undergoing dialysis and 38 healthy controls.
- Diffusion tensor imaging (DTI) was performed using a 3T scanner.
- The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was calculated and compared between groups.
Main Results:
- Patients with ESRD showed a significantly lower DTI-ALPS index compared to healthy controls (1.460 vs. 1.632, p = 0.003).
- A significant positive correlation was observed between the DTI-ALPS index and serum parathyroid hormone levels in ESRD patients (r = 0.357, p = 0.011).
Conclusions:
- Glymphatic dysfunction is evident in patients with ESRD, as demonstrated by the DTI-ALPS index.
- The DTI-ALPS method is feasible for assessing glymphatic function in ESRD patients, supporting its use in future research.
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