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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Peripheral Ossifying Fibroma Evolved From Pyogenic Granuloma.

Géssica V Godinho1, Cristhiane A Silva2, Bruno R Noronha1

  • 1Department of Dentistry, Hospital de Câncer de Mato Grosso, Cuiabá, BRA.

Cureus
|February 11, 2022
PubMed
Summary

This case study shows a rare evolution of pyogenic granuloma into a peripheral ossifying fibroma in a 50-year-old woman. Surgical excision and follow-up confirmed successful treatment without recurrence.

Keywords:
excisional tissue biopsygingival growthgingival neoplasmsossifying fibromapyogenic granuloma

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Area of Science:

  • Oral pathology
  • Dermatology
  • Oncology

Background:

  • Pyogenic granulomas are common benign oral lesions.
  • Peripheral ossifying fibromas are rare gingival tumors.

Observation:

  • A 50-year-old woman presented with a large, 7-year-evolving lesion initially diagnosed as pyogenic granuloma.
  • After 3 years, the lesion significantly increased in size and changed in appearance.

Findings:

  • Histopathological examination confirmed the lesion as a peripheral ossifying fibroma.
  • The tumor showed calcified material, fibrous maturation, and reduced vascularity compared to the initial pyogenic granuloma.

Implications:

  • This case suggests a potential malignant transformation pathway from pyogenic granuloma to peripheral ossifying fibroma.
  • Understanding this evolution is crucial for accurate diagnosis and treatment of oral lesions.