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Related Experiment Videos

Extended EMIT-DAU phencyclidine screen.

F A Ragan, S A Hite, M S Samuels

    The Journal of Clinical Psychiatry
    |April 1, 1986
    PubMed
    Summary
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    An enhanced urine screen for phencyclidine (PCP) significantly increased detection rates compared to the routine method. This improved screening helps rapidly identify PCP use in psychiatric patients, reducing the need for further confirmation. Keywords: phencyclidine, PCP, urine drug screen, psychiatric population.

    Area of Science:

    • Forensic Toxicology
    • Clinical Chemistry
    • Psychiatric Diagnostics

    Background:

    • Phencyclidine (PCP) is a dissociative drug associated with acute psychosis and abnormal behavior.
    • Accurate and rapid screening for PCP in emergency settings is crucial for patient management.
    • Existing screening methods may have limitations in sensitivity and specificity.

    Purpose of the Study:

    • To evaluate the performance of an extended EMIT-DAU PCP screen compared to a routine screen and gas chromatograph/mass spectrometer/computer (GC/MS/COMP).
    • To determine the increase in PCP detection and the efficiency of negative result reporting.
    • To assess the utility of the enhanced screen in a psychiatric emergency room population.

    Main Methods:

    • Screening of 580 urines using routine EMIT-DAU PCP, extended EMIT-DAU PCP, and GC/MS/COMP (reference method).

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  • Comparison of positive detection rates between the routine and extended EMIT-DAU PCP screens.
  • Analysis of the percentage of negative specimens that could be reported without GC/MS/COMP confirmation.

    • Main Results:

    • The extended EMIT-DAU PCP screen identified 38.5% more positive cases than the routine screen.
    • 66.4% of specimens were identified as negative by the extended screen, allowing for rapid reporting without GC/MS/COMP.
    • The enhanced method offers a faster and more cost-effective approach to PCP screening.

    Conclusions:

    • The extended EMIT-DAU PCP screen provides a significant improvement in detecting phencyclidine in urine samples.
    • This method enhances efficiency by allowing a substantial proportion of negative results to be reported quickly.
    • The rapid and reliable screening of PCP is particularly valuable in managing patients within psychiatric emergency settings.