Related Experiment Video
Updated: Oct 4, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
Calvarial lytic lesions in neurosyphilis with ocular involvement
Michael F Chan1, Fekadesilassie Moges1, Dawit Major1
1Department of Internal Medicine, Aurora St. Luke's Medical Center, Advocate Aurora Health, 2900 W Oklahoma Ave, Milwaukee, WI 53215, USA.
Abstract:
We report a case of calvarial lytic lesions in neurosyphilis with ocular involvement. A 42-year-old woman with a past medical history of polysubstance abuse presented with recent bilateral vision loss. CT revealed numerous calvarial lytic lesions and multiple myeloma was initially suspected. Syphilis screening with RPR and confirmative CSF studies were positive for active infection. The patient was treated with Penicillin G and demonstrated clinical improvement. The objective of this study was to provide insight into a rare manifestation of syphilis with osseous involvement and encourage further discourse into establishment of standards of care for syphilitic osteomyelitis. There exist no evidence-based guidelines regarding optimal treatment route and duration, role of bone biopsy, determination of therapeutic impact, and threshold for surgical intervention in the management of syphilitic osteomyelitis.
More Related Videos
Related Concept Videos
Sexually Transmitted Infections
Glaucoma: Overview
Endocarditis II: Clinical Features of Infective Endocarditis
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...

