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The China birth cohort study (CBCS).

Wentao Yue1, Enjie Zhang1, Ruixia Liu1

  • 1Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, People's Republic of China.

European Journal of Epidemiology
|February 11, 2022
PubMed
Summary
This summary is machine-generated.

The China birth cohort study (CBCS) is a large national study investigating birth defect causes. It has enrolled over 120,000 pregnant women, with 2.5% experiencing birth defects, most commonly congenital heart disease.

Keywords:
Birth defectsChinaCohort studyPregnancy

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Area of Science:

  • Reproductive Medicine
  • Pediatrics
  • Genetics

Background:

  • The China birth cohort study (CBCS) is the first national prospective, longitudinal mega-cohort study in China.
  • It aims to establish a representative birth cohort to investigate risk factors for birth defects and inform reduction strategies.

Purpose of the Study:

  • To identify risk factors associated with birth defects.
  • To develop strategies for the prevention and reduction of birth defects.
  • To create a comprehensive national birth cohort for ongoing research.

Main Methods:

  • Prospective longitudinal mega-cohort design.
  • Recruitment of pregnant women (6-13+6 weeks gestation) across China.
  • In-person interviews at 20-23+6 and 28-33+6 weeks gestation, and at delivery.
  • Collection of biological samples (blood, amniocytes, cord blood, placenta, umbilical cord).

Main Results:

  • As of February 29, 2020, 120,377 pregnant women were enrolled in the first two phases.
  • 40,837 participants were followed to the end of pregnancy during the same period.
  • The incidence of birth defects is 2.5%, with congenital heart disease being the most common.
  • Study recruitment aims for 500,000 participants by December 2021.

Conclusions:

  • The CBCS is a significant national effort to understand and address birth defects.
  • Early findings indicate a 2.5% birth defect rate, highlighting the need for continued research.
  • The study infrastructure will facilitate global collaboration in birth defect research.