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Lower Rates of Emergency Department Visits and Hospitalizations Among Patients With Chronic Hepatitis C With

Stuart C Gordon1,2, Eyasu H Teshale3, Philip R Spradling3

  • 1Department of Gastroenterology and Hepatology, Henry Ford Health System, Detroit Michigan, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|February 11, 2022
PubMed

Insights

Patients with hepatitis C virus (HCV) achieving sustained virological response after direct-acting antiviral therapy had fewer emergency department visits and hospitalizations. This demonstrates the significant health benefits of successful HCV treatment.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection poses a significant global health burden.
  • Direct-acting antiviral (DAA) therapies have revolutionized HCV treatment, leading to high rates of sustained virological response (SVR).
  • Understanding the long-term impact of SVR on healthcare utilization is crucial for resource planning and patient management.

Purpose of the Study:

  • To compare the rates of emergency department (ED) visits and hospitalizations between HCV patients who achieved SVR after DAA therapy and matched controls.
  • To assess the impact of successful HCV treatment on liver-related and all-cause healthcare utilization.

Main Methods:

  • A retrospective cohort study design was employed.
  • 3049 pairs of patients achieving SVR after DAA therapy (case patients) and matched controls were analyzed.
  • Rates of liver-related ED visits, all-cause hospitalizations, liver-related hospitalizations, and hospitalized days were compared between groups.

Main Results:

  • Case patients showed significantly lower rates of liver-related ED visits compared to controls (P = .01).
  • All-cause hospitalization rates, liver-related hospitalization rates, and the number of hospitalized days were significantly lower in case patients (P < .001).

Conclusions:

  • Achieving sustained virological response after direct-acting antiviral therapy for hepatitis C virus is associated with reduced healthcare utilization.
  • Successful HCV treatment leads to decreased emergency department visits and hospitalizations, highlighting the clinical and economic benefits of DAA therapy.

Keywords:
EDHCVSVRhealthcare utilizationrace

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