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A case of acute poststreptococcal glomerulonephritis complicated by interstitial nephritis related to streptococcal

Nobuhiro Kanazawa1, Masayuki Iyoda1,2, Junichi Hayashi1

  • 1Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Pathology International
|February 11, 2022
PubMed

Insights

This case study reveals that streptococcal pyrogenic exotoxin B (SpeB) may contribute to acute kidney injury and nephrotic syndrome after skin infections. SpeB toxicity might play a role in tubulointerstitial nephritis following post-streptococcal conditions.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pathology

Background:

  • Post-streptococcal glomerulonephritis (PSGN) is a common complication of streptococcal infections.
  • Acute kidney injury (AKI) and nephrotic syndrome can occur following streptococcal cutaneous infections.
  • The pathogenesis of tubulointerstitial nephritis (TIN) in PSGN is not fully understood.
Keywords:
nephritis-associated plasmin receptorpoststreptococcal glomerulonephritisstreptococcal pyrogenic exotoxin Btubulointerstitial nephritis

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