Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complexities of intraventricular abnormalities.

B R Pober, M F Greene, L B Holmes

    The Journal of Pediatrics
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hypercalciuria and nephrolithiasis: Expanding the renal phenotype of Donnai-Barrow syndrome.

    Clinical genetics·2018
    Same author

    Description of common musculoskeletal findings in Williams Syndrome and implications for therapies.

    Clinical anatomy (New York, N.Y.)·2016
    Same author

    Prevalence and penetrance of ZFPM2 mutations and deletions causing congenital diaphragmatic hernia.

    Clinical genetics·2014
    Same author

    Comparative safety of antiepileptic drugs during pregnancy.

    Neurology·2012
    Same author

    High prevalence of diabetes and pre-diabetes in adults with Williams syndrome.

    American journal of medical genetics. Part C, Seminars in medical genetics·2010
    Same author

    Genetic aspects of human congenital diaphragmatic hernia.

    Clinical genetics·2008
    Same journal

    Standardized Mean Differences Reveal Substantial Selection Bias in Post-Reduction Management of Intussusception.

    The Journal of pediatrics·2026
    Same journal

    Parenteral Lipid Dose and Bilirubin Neurotoxicity in Extremely Preterm Infants: A Factorial Randomized Trial.

    The Journal of pediatrics·2026
    Same journal

    Refining Oxygen-Carrying Capacity Metrics in Assessing Mortality Risk from Pneumonia in Children.

    The Journal of pediatrics·2026
    Same journal

    Time-to-Transfer and Hospitalization Duration for Severe Congenital Heart Defects: Implications for Perinatal Regionalization.

    The Journal of pediatrics·2026
    Same journal

    Multimodal neuromonitoring in neonatal hypoxic-ischemic encephalopathy and the association with neurodevelopmental outcomes: A Multicenter Study.

    The Journal of pediatrics·2026
    Same journal

    KP.2-Adapted BNT162b2 COVID-19 Vaccine Uptake and Effectiveness in Children.

    The Journal of pediatrics·2026
    See all related articles

    Intracranial anomalies in fetuses and infants are linked to poor survival rates and frequent associated malformations. Prenatal ultrasound diagnosis is common, but accuracy varies, making in utero treatment inadvisable.

    Area of Science:

    • Medical imaging
    • Prenatal diagnosis
    • Neonatal neurology

    Background:

    • Intracranial anomalies encompass a range of conditions affecting fetal brain development.
    • These anomalies present significant challenges in diagnosis, management, and prognosis.
    • Understanding the spectrum and outcomes of these conditions is crucial for clinical practice.

    Purpose of the Study:

    • To analyze the diagnostic accuracy of prenatal ultrasound for intracranial anomalies.
    • To evaluate the survival rates and associated malformations in affected fetuses and infants.
    • To assess the feasibility and appropriateness of in utero treatment for ventriculomegaly.

    Main Methods:

    • Retrospective review of 59 cases of fetal and infant intracranial anomalies over 5.5 years.

    Related Experiment Videos

  • Analysis of diagnostic groups including hydrocephalus, holoprosencephaly, and hydranencephaly.
  • Evaluation of prenatal ultrasound diagnostic accuracy, associated anomalies, chromosomal abnormalities, and survival outcomes.

    • Main Results:

    • Prenatal ultrasound diagnosed 50 of 59 cases, with accuracy ranging from 90% for hydrocephalus to 33% for holoprosencephaly/hydranencephaly.
    • Associated non-neural tube malformations were present in 19/54 cases, and chromosomal abnormalities in 8/32 cases.
    • Survival was poor, with 13/59 terminations, 10/59 stillbirths, and 16/38 liveborn infants dying postnatally.

    Conclusions:

    • Thorough diagnostic evaluation including ultrasound and chromosome studies is recommended.
    • Parents should be informed about high associated anomaly rates, poor prognosis, and ultrasound limitations.
    • Current evidence suggests in utero treatment for fetal ventriculomegaly is inadvisable.