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Establishment of A Mouse Model of Aqueous Deficiency Dry Eye
Published on: November 1, 2024
785
[Dry eye and qualitative tear alteration in essential blepharospasm]
1Service d'ophtalmologie, hôpital Tenon, Assistance publique-Hôpitaux de Paris, 4, rue de la Chine, 75970 Paris cedex 20, France; UPMC Sorbonne université, Paris, France.
Journal Francais D'Ophtalmologie
|February 12, 2022
Summary
Benign Essential Blepharospasm (BEB) patients exhibit dry eye and basic tear pH, linked to conjunctival inflammation. These findings suggest corneo-conjunctival mechanisms contribute to BEB symptoms like photophobia and pain.
Area of Science:
- Ophthalmology
- Neuro-ophthalmology
Background:
- Benign Essential Blepharospasm (BEB) is a common neurological disorder.
- BEB symptoms include photophobia, dry eye, and ocular pain, with unclear underlying mechanisms.
Purpose of the Study:
- To investigate potential corneo-conjunctival mechanisms contributing to photophobia, tear deficiency, and ocular pain in BEB patients.
- To analyze tear film characteristics and conjunctival status in individuals with BEB.
Main Methods:
- Observational cohort study of 42 BEB patients.
- Utilized Schirmer's testing, tear film pH measurement, tear protein electrophoresis, and conjunctival impression cytology.
Main Results:
- Schirmer's testing indicated dry eye in 71.3% of eyes (Schirmer's score <10mm).
- Tear film pH was found to be basic (8.4±0.4), with improvement noted in patients receiving botulinum toxin injections.
- Tear protein electrophoresis and conjunctival cytology revealed conjunctival inflammation associated with BEB.
Conclusions:
- This study highlights corneo-conjunctival mechanisms as a significant factor in BEB-related photophobia, dry eye, and pain.
- Further research is needed to assess the impact of normalizing tear film pH and reducing inflammation on patient quality of life.
Keywords:
Acidité lacrymaleBEBBSEBlepharospasmBlépharospasmeBlépharospasme essentielBotulinum toxinConjunctival impressionDry eye syndromeEmpreinte conjonctivaleEssential BlepharospasmInflammation conjonctivaleInsuffisance lacrymalePHSchirmerSyndrome secTear acidityTear deficiencyTear electrophoresisToxine botuliqueconjunctival inflammationÉlectrophorèse lacrymaleRelated Concept Videos
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