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Oligonucleotides-transformers for molecular biology and nanoengineering
Stanislav S Bachurin1, Mikhail E Kletskii2, Oleg N Burov2
1Rostov State Medical University, 29 Nakhichevanskiy Lane, Rostov-on-Don 344022, Russian Federation.
Gene
|February 12, 2022
Summary
Non-canonical DNA structures (NSs) like G-quadruplexes are crucial for epigenetics and nanotechnology. Oligonucleotide-transformers, predicted by the Dafna algorithm, can form multiple NSs for novel applications.
Area of Science:
- Molecular Biology
- Nanotechnology
- Bioinformatics
Background:
- Non-canonical DNA structures (NSs) are vital in biological processes and nanotechnology.
- NSs include G-quadruplex, i-motif, hairpin, and triplex structures.
- These structures exhibit low-energy conformational changes.
Purpose of the Study:
- To review experimental and theoretical data on non-canonical DNA structures.
- To analyze the properties and applications of oligonucleotide-transformers.
- To explore the potential of these transformers in nanoengineering and genetic editing.
Main Methods:
- Analysis of experimental and theoretical data on NSs.
- Review of computational predictions for oligonucleotide-transformers using automata and graph theories ('Dafna' algorithm).
Main Results:
- Oligonucleotide-transformers can fold into multiple NSs.
- NSs are implicated in epigenetic regulation and viral genetic variability.
- NSs show promise for nanoscale device design.
Conclusions:
- Oligonucleotide-transformers represent a significant advancement in DNA nanotechnology.
- These sequences have potential applications in nanoengineering and genetic editing.
- Further research into NSs and transformers is warranted.
