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Published on: August 8, 2019
Cystic Fibrosis and Sleep Circadian Rhythms
Mariam Louis1, Peter Staiano1, Lavender Micalo2
1Department of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Jacksonville, FL, USA.
Abstract:
Cystic fibrosis (CF) is due to a mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to unusual water and chloride secretion across epithelial surfaces. The lungs are responsible for most morbidity, though other organs are frequently affected. Sleep abnormalities have long been recognized in CF. Abnormal ventilation and oxygenation, sinus disease, deconditioning due to muscle weakness and recurrent infections, and inflammation have been thought to play a role in sleep disorders in CF. However, there is evidence that CFTR gene dysregulation can affect circadian rhythms in CF. Early recognition and treatment of circadian rhythms may improve outcomes in CF.
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