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Porocarcinoma: a review.
Jilse Joshy1, Khaylen Mistry1,2, Nick J Levell1,2
1Norwich Medical School, University of East Anglia, Norwich, UK.
Clinical and Experimental Dermatology
|February 12, 2022
Summary
Eccrine porocarcinoma (PC) diagnosis is challenging due to its rarity and varied presentation. This rare sweat gland neoplasm has a poor prognosis, with a high recurrence rate after treatment.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Eccrine porocarcinoma (PC) is a rare sweat gland neoplasm.
- Diagnosis and management remain challenging, with limited understanding of its epidemiology and pathogenesis.
Purpose of the Study:
- To provide a concise update on the history, pathogenesis, epidemiology, diagnosis, management, and prognosis of eccrine porocarcinoma.
- To highlight diagnostic difficulties and treatment outcomes for this rare malignancy.
Main Methods:
- This review synthesizes current knowledge on eccrine porocarcinoma.
- Information was gathered on PC's clinical presentation, histological features, incidence, and treatment strategies.
Main Results:
- Eccrine porocarcinoma typically affects individuals over 60, often on the head, neck, and legs.
- Diagnosis is difficult due to variable presentations mimicking squamous cell carcinoma.
- Wide local excision or Mohs surgery are standard treatments, but recurrence rates are high (35%).
Conclusions:
- Eccrine porocarcinoma presents diagnostic and therapeutic challenges.
- The prognosis is often poor, emphasizing the need for further research.
- Standardized protocols and risk profiles are lacking, necessitating additional studies to improve PC understanding and patient outcomes.
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