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Updated: Oct 3, 2025

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
12:42

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Published on: August 28, 2012

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CTLA-4 polymorphism contributes to the genetic susceptibility of epithelial ovarian cancer

Juan Chen1, Shan Kang1, Jianlei Wu1

  • 1Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.

The Journal of Obstetrics and Gynaecology Research
|February 12, 2022
PubMed
Abstract

Insights

The CTLA-4 rs5742909 C/T polymorphism may reduce the risk of developing epithelial ovarian cancer in northern Chinese women. This specific CTLA-4 gene variant was associated with decreased genetic susceptibility to this cancer.

Area of Science:

  • Immunogenetics
  • Cancer Genetics
  • Molecular Epidemiology

Background:

  • Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an inhibitory T-cell molecule crucial in cancer development.
  • Understanding genetic variations in CTLA-4 can offer insights into cancer susceptibility.

Purpose of the Study:

  • To investigate the association between CTLA-4 gene polymorphisms and epithelial ovarian cancer risk.
  • To evaluate the impact of these polymorphisms on patient clinical outcomes.

Main Methods:

  • A case-control study involving 527 epithelial ovarian cancer patients and 532 controls.
  • Genotyping of three CTLA-4 polymorphisms (rs5742909, rs231775, rs3087243) using PCR/LDR.
  • Survival analysis was conducted on patient cohorts with 3-year and 5-year follow-ups.

Main Results:

  • The rs5742909 C/T polymorphism showed significant differences in genotype and allele frequencies between cases and controls (p=0.009, p=0.04).
  • Carriers of the CT or TT genotypes for rs5742909 had a reduced risk of epithelial ovarian cancer (OR=0.69).
  • No significant associations were found for rs231775 and rs3087243 polymorphisms with cancer risk or for any of the three polymorphisms with clinical outcomes.

Conclusions:

  • The CTLA-4 rs5742909 C/T polymorphism is associated with a decreased genetic susceptibility to epithelial ovarian cancer.
  • This finding is specific to the northern Chinese female population studied.
  • CTLA-4 polymorphisms did not appear to influence the clinical outcomes in this patient group.
Keywords:
CTLA-4clinical outcomeepithelial ovarian cancergenetic susceptibilitypolymorphism

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