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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Multi-Cue Kinetic Model with Non-Local Sensing for Cell Migration on a Fiber Network with Chemotaxis.

Martina Conte1, Nadia Loy1

  • 1Department of Mathematical Sciences, "G. L. Lagrange", Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Torino, Italy.

Bulletin of Mathematical Biology
|February 12, 2022
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Summary
This summary is machine-generated.

Cells migrate by sensing multiple environmental cues, like contact guidance and chemotaxis. This study models cell polarization to understand how cells integrate these signals, revealing the importance of hyperbolic models for predicting cell motility.

Keywords:
ChemotaxisContact guidanceHydrodynamic limitMulti-cue cell migrationMultiscale modelingNon-local kinetic equations

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Area of Science:

  • Cell Biology
  • Biophysics
  • Mathematical Modeling

Background:

  • Cells exhibit directed motion (taxis) in response to environmental stimuli.
  • Cells integrate multiple biochemical and biophysical cues for navigation.
  • Understanding multi-cue sensing is crucial for cell migration dynamics.

Purpose of the Study:

  • To develop a non-local kinetic model for cell migration influenced by contact guidance and chemotaxis.
  • To analyze cell polarization and behavior under combined external fields.
  • To investigate the role of cell size and sensing strategies in multi-cue environments.

Main Methods:

  • Proposed a non-local kinetic model for cell migration.
  • Developed two distinct sensing strategies.
  • Analyzed macroscopic limits of transport kinetic models.
  • Numerically integrated kinetic transport equations in 2D.
  • Compared hyperbolic models with drift-diffusion models.

Main Results:

  • Demonstrated the importance of hyperbolic models over drift-diffusion models for cell migration.
  • Showcased how cell size influences migration behavior in varying external fields.
  • Successfully reproduced experimental findings on topographical and chemical cue influence on cell motility.

Conclusions:

  • The developed kinetic model accurately describes cell migration in multi-cue environments.
  • Hyperbolic models provide a more suitable framework for understanding cell polarization and directed motion.
  • The study offers insights into how cells integrate diverse environmental signals for navigation.