Related Experiment Video
Updated: Oct 3, 2025

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
Published on: May 2, 2025
The Symptom Experience in Pediatric Cancer: Current Conceptualizations and Future Directions
Lindsay A Jibb1,2, Suzanne Ameringer3, Catherine Fiona Macpherson4
1Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, 155 College Street, M5T 1P8, Toronto, Canada. lindsay.jibb@sickkids.ca.
Insights
Understanding childhood cancer symptoms requires considering biology, family, and environment. Research gaps exist in symptom assessment and management partnerships, necessitating personalized care strategies.
Area of Science:
- Pediatric Oncology
- Symptom Management
- Quality of Life Research
Background:
- Childhood cancer symptoms are prevalent and distressing, significantly impacting quality of life for both children and their families.
- Numerous interacting factors, including socioeconomic status, biology, genetics, psychosocial dynamics, and environmental influences, shape the childhood cancer symptom experience.
- Current research has identified gaps in routine symptom assessment and the establishment of effective family-centered symptom management strategies.
Purpose of the Study:
- To review recent research on the childhood cancer symptom experience.
- To identify factors influencing symptom experience, including socioeconomic, biological, genetic, psychosocial, and environmental aspects.
- To formulate recommendations for a personalized approach to symptom management in pediatric oncology.
Main Methods:
- Literature review of recent research on childhood cancer symptom experience.
- Analysis of factors influencing symptom presentation and impact.
- Synthesis of findings to identify research gaps and clinical implications.
Main Results:
- Childhood cancer symptom experience is multifactorial, influenced by biological, genetic, developmental, family, and environmental factors.
- Significant gaps exist in routine symptom assessment and the integration of family psychosocial dynamics into care.
- Socioeconomic factors play a crucial role in symptom experience and access to care.
Conclusions:
- Personalized symptom management strategies are essential for improving outcomes in pediatric oncology.
- Future research should focus on addressing identified gaps in assessment and family-centered care.
- Translating research findings into clinical practice is critical for enhancing the quality of life for children with cancer.
Purpose Of Review:
We aimed to review the recent research on the childhood cancer symptom experience pertaining to socioeconomic factors, biology and genetics, growth and development, family psychosocial dynamics, and social and treating environments to begin to formulate recommendations for a personalized approach to symptom management.
Recent Findings:
Cancer symptoms are common and distressing in children and negatively impact child and family quality of life. Many interacting factors influence children's cancer symptoms experiences, including the assessment and management of such symptoms. This paper highlights several gaps in the research related to the cancer symptom experience including routine symptom assessment, the impact of socioeconomic, biological, and genetic factors on symptoms, and the establishment of effective symptom management partnerships with families. Based on our findings, we provide recommendations related to that research which is ready to be implemented into clinical practice and areas for needed future efforts.
Related Concept Videos
Cancer Survival Analysis
Treatment Resistant Cancers
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Tumor Immunotherapy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

