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Related Experiment Videos

Magnesium and cell cycle control: an update.

G M Walker

    Magnesium
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Magnesium plays a universal role in controlling the cell cycle across organisms, from bacteria to human cells. Its regulation is crucial for cell proliferation and may be altered in cancer development.

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    Area of Science:

    • Cell Biology
    • Biochemistry
    • Oncology

    Background:

    • Magnesium is increasingly recognized for its fundamental role in cellular processes.
    • Evidence suggests magnesium influences the cell cycle universally across diverse life forms.

    Purpose of the Study:

    • To elucidate the universal role of magnesium in cell cycle control.
    • To explore magnesium's involvement in cell proliferation and oncogenesis.

    Main Methods:

    • Review of accumulating evidence from bacterial, yeast, and mammalian cell studies.
    • Analysis of magnesium's effects on key cell cycle regulatory points.

    Main Results:

    • Magnesium modulates cell cycle events, including DNA synthesis and mitosis in mammalian cells.

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  • Differential magnesium affinities for growth and division observed in bacteria.
  • Cell cycle-dependent intracellular magnesium fluxes postulated to regulate yeast proliferation.
  • Cell transformation can lead to a loss of magnesium's regulatory role.

    • Conclusions:

    • Magnesium is a universal regulator of the cell cycle.
    • Disruption of magnesium's regulatory role in the cell cycle is implicated in oncogenesis and malignancy.