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A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
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Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

Alba Escalera1, Ana S Gonzalez-Reiche2, Sadaf Aslam3

  • 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Cell Host & Microbe
|February 12, 2022
PubMed

Keywords:
H655Y mutationSARS-CoV-2fusiongammaomicronspike cleavagesyncytia formationvariants of concern

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