Acute stress promotes brain oscillations and hippocampal-cortical dialog in emotional processing

Hippocampal-cortical circuit oscillations in local field potential (LFP) represent network-level signals which promotes behavior. Investigating these signals promote our understanding on how the brain process cognition and emotion, and provide further perspectives into electroencephalogram endophenotypes, especially under the pathological state. The physiological adaptive stress responses to threatening stimuli are critical for individuals. The disturbance of stress response may lead to psychiatric disorders such as major depressive disorder (MDD). To quantitatively examine the effects of acute stress on hippocampal-cortical circuit, we recorded LFPs in the hippocampus (HC) and the medial prefrontal cortex (mPFC). We analyzed three major LFP oscillations with their temporal coupling. Consistent with our hypothesis that strengthened communication of hippocampal-cortical circuit may occur in stress adaption, we found that intensive acute stress induced enhanced ripple-delta-spindle coupling. The LFP coupling may facilitate the recruitment of relevant structures in hippocampal-cortical circuit, in response to acute stress, and play a role in emotional encoding migration.