Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future

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Lele Zhang1, Jifa Zhang1, Jiaxing Wang2

  • 1Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Joint Research Institution of Altitude Health, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; State Key Laboratory of Biotherapy and Cancer Center, Department of Respiratory and Critical Care Medicine, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

European Journal of Medicinal Chemistry
|February 12, 2022
PubMed

Keywords:
AnticancerHuman dihydroorotate dehydrogenase (hDHODH)Small molecule inhibitorsStructure-activity relationships (SARs)

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