Related Experiment Video
Updated: Oct 3, 2025
05:14
Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
Published on: November 18, 2022
9.8K
Gut barrier disruption and chronic disease
Jan Martel1, Shih-Hsin Chang2, Yun-Fei Ko3
1Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Trends in Endocrinology and Metabolism: TEM
|February 13, 2022
Summary
The gut barrier protects against harmful substances, but disruption can cause inflammation and disease. Emerging research suggests interventions targeting gut barrier integrity and microbiota may help treat metabolic, autoimmune, and aging-related disorders.
Area of Science:
- Gastroenterology
- Immunology
- Microbiology
Background:
- The intestinal barrier is crucial for host defense against gut microbes, antigens, and toxins.
- Factors like diet, antibiotics, stress, and aging can compromise gut barrier integrity.
- Chronic disruption leads to microbial translocation and systemic inflammation.
Purpose of the Study:
- To review recent studies on the gut barrier's role beyond intestinal diseases.
- To explore the contribution of gut barrier dysfunction and microbiota dysbiosis to metabolic, autoimmune, and aging-related disorders.
- To describe emerging interventions for improving gut barrier function and microbiota composition.
Main Methods:
- Literature review of recent scientific studies.
- Analysis of the relationship between gut barrier integrity, microbiota dysbiosis, and systemic diseases.
- Identification and description of novel therapeutic strategies.
Main Results:
- Gut barrier dysfunction and microbiota dysbiosis are implicated in metabolic, autoimmune, and aging-related disorders.
- Systemic inflammation is a consequence of microbial translocation due to compromised gut barrier.
- Several interventions show promise in restoring gut barrier integrity and microbiota balance.
Conclusions:
- The gut barrier plays a significant role in systemic health, influencing metabolic, autoimmune, and aging processes.
- Maintaining gut barrier integrity and a balanced microbiota is essential for preventing and managing chronic diseases.
- Future research and therapeutic strategies should focus on gut barrier health and microbiota modulation.
Related Concept Videos
01:17Chronic Bowel Disorders: Introduction
554
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
554
01:24Chronic Pancreatitis I: Introduction
187
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
187
01:05Physiology of Enteric Nervous System and Gut Health
467
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
467
01:17Gastritis-II: Pathophysiology
666
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
666
01:30Inflammatory Bowel Disease II: Crohn's Disease
435
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
435
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
638
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
638