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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
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Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin
Kai Matuschewski1, Alexander G Maier2
1Department of Molecular Parasitology, Institute of Biology, Humboldt University, Berlin, Germany.
Trends in Parasitology
|February 13, 2022
Abstract:
The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.
Keywords:
allele frequencybalanced polymorphismgenetic epidemiologyhemoglobin Ssevere malariasickle cellMore Related Videos
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