Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

788
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
788
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.5K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.4K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.4K
Incomplete Dominance01:43

Incomplete Dominance

26.1K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
26.1K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

178
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
178
Dosage Compensation02:50

Dosage Compensation

6.4K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with  distinct numbers of X chromosomes will...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges and opportunities of gap score methods for studying psychopathology resilience and vulnerability.

medRxiv : the preprint server for health sciences·2026
Same author

Bidirectional associations between cannabis use, oddball performance and P3 event-related potential.

medRxiv : the preprint server for health sciences·2026
Same author

Sense of Purpose and Maladaptive Personality Traits in Older Adulthood.

International journal of aging & human development·2026
Same author

Prenatal Substance Exposure and Birth Weight: Findings From the HEALthy Brain and Child Development Study.

Pediatrics·2026
Same author

Associations Between Prenatal Cannabis Exposure and Birth Outcomes: Results from a Prospective Cohort Study.

medRxiv : the preprint server for health sciences·2026
Same author

A phenome-wide association study of cross-disorder genetic liability in youth genetically similar to individuals from European reference populations.

Nature. Mental health·2026

Related Experiment Video

Updated: Oct 3, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

19.1K

Understanding Anhedonia from a Genomic Perspective.

Erin Bondy1, Ryan Bogdan2

  • 1Department of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA.

Current Topics in Behavioral Neurosciences
|February 13, 2022
PubMed
Summary

Anhedonia, the inability to feel pleasure, is a heritable trait linked to depression. Genomic studies reveal shared genetic links with depression, schizophrenia, and brain structure, offering etiological insights.

Keywords:
AnhedoniaBrainDepressionGWASGeneRewardStriatum

More Related Videos

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K
The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

17.8K

Related Experiment Videos

Last Updated: Oct 3, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

19.1K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K
The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

17.8K

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Anhedonia is a core symptom of major depression and other disorders.
  • It is considered a heritable vulnerability marker for depression, with moderate to large heritability.
  • Understanding the genetic basis of anhedonia is crucial for psychiatric research.

Purpose of the Study:

  • To review the current understanding of the genomic architecture underlying anhedonia.
  • To discuss findings from twin, candidate gene, and genome-wide association studies (GWAS).
  • To explore the genetic overlap of anhedonia with other psychiatric conditions and brain structures.

Main Methods:

  • Review of existing literature on twin studies, candidate gene association studies, and GWAS.
  • Focus on polygenic analyses and their implications for understanding complex genetic traits.
  • Discussion of challenges in genomic research for anhedonia due to sample size and phenotyping limitations.

Main Results:

  • Few GWAS studies on anhedonia-related constructs exist due to sample size limitations, leading to underpowered results.
  • Identified polygenic architecture shows genetic overlap with depression, schizophrenia, and striatal volume.
  • These findings provide etiological clues and may inform nosological refinement.

Conclusions:

  • The genomic architecture of anhedonia shares significant overlap with depression and schizophrenia.
  • Novel analytical techniques can leverage existing GWAS data to explore these relationships.
  • Further large-scale studies are needed for well-powered GWAS of reward-related constructs.