Related Experiment Video
Updated: Oct 3, 2025
13:04
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
Published on: March 1, 2019
9.0K
Long Non-Coding RNAs and Obesity: New Potential Pathogenic Biomarkers
Martina Fontanini1, Manuela Cabiati1, Manuel Giacomarra1
1CNR Institute of Clinical Physiology, Biochemistry and Molecular Biology laboratory, Via G. Moruzzi 1, 56124 Pisa Italy.
Current Pharmaceutical Design
|February 14, 2022
Summary
Long non-coding RNAs (lncRNAs) play a role in obesity by regulating adipogenesis and lipid metabolism. Understanding these lncRNAs could lead to new therapeutic strategies for combating obesity.
Area of Science:
- Genomics
- Molecular Biology
- Biochemistry
Background:
- Long non-coding RNAs (lncRNAs) are crucial regulators of biological processes.
- Obesity is a global health concern affecting children and adults.
- Identifying early biomarkers for obesity is essential for timely intervention.
Purpose of the Study:
- To review the role of lncRNAs in obesity.
- To highlight lncRNAs involved in adipogenesis and lipid metabolism.
- To explore the potential of lncRNAs in obesity treatment.
Main Methods:
- Literature review of studies on lncRNAs and obesity.
- Analysis of lncRNA involvement in adipogenesis.
- Investigation of lncRNA regulation of lipid metabolism, specifically lipogenesis.
Main Results:
- lncRNAs are implicated in the complex mechanisms of adipogenesis.
- Specific lncRNAs influence lipid metabolism and lipogenesis pathways.
- Dysregulation of certain lncRNAs is associated with obesity development.
Conclusions:
- lncRNAs at the intersection of adipogenesis and lipogenesis are key players in obesity.
- Further research into these lncRNAs may reveal causative links to obesity.
- lncRNAs present potential therapeutic targets for novel anti-obesity strategies.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
9.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
03:18Non-LTR Retrotransposons
12.0K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.0K
01:24Obesity
669
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
669
01:13Formation of Muscle Fibers from Myoblasts
5.3K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
5.3K