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Updated: Oct 3, 2025

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Quercetin and Glioma: Which Signaling Pathways are Involved?

Omid Reza Tamtaji1,2, Zahra Sadat Razavi3, Nazanin Razzaghi4

  • 1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.

Current Molecular Pharmacology
|February 14, 2022
PubMed

Insights

Quercetin, a natural flavonoid, shows promise in combating gliomas (brain tumors) by targeting key cellular processes. Further research into these pathways could lead to improved glioma treatments.

Area of Science:

  • Oncology
  • Neuroscience
  • Pharmacology

Background:

  • Gliomas are the most prevalent brain tumors, characterized by continuous growth and resistance to conventional therapies.
  • Current glioma treatments offer limited efficacy due to aggressive metastasis and drug resistance, highlighting the need for novel therapeutic strategies.
  • Quercetin, a plant-derived flavonoid, possesses demonstrated antioxidant, anti-inflammatory, and anticancer properties.

Purpose of the Study:

  • To summarize the cellular and molecular pathways influenced by quercetin in glioma treatment.
  • To explore the anti-tumor effects of quercetin on glioma progression.
  • To provide a comprehensive overview of quercetin's potential as a therapeutic agent for gliomas.

Main Methods:

  • Literature review of studies investigating quercetin's effects on glioma cells.
  • Analysis of molecular mechanisms targeted by quercetin, including apoptosis, autophagy, and metastasis.
  • Synthesis of evidence on quercetin's pharmacological actions in preclinical glioma models.

Main Results:

  • Quercetin exhibits significant anti-tumor activity against gliomas through various mechanisms.
  • The compound modulates critical cellular processes such as apoptosis induction and inhibition of metastasis.
  • Quercetin's effects on autophagy pathways suggest a role in regulating tumor cell survival and response to therapy.

Conclusions:

  • Quercetin demonstrates considerable potential as a therapeutic agent for gliomas.
  • Targeting cellular and molecular pathways with quercetin offers a promising avenue for overcoming limitations in current glioma treatments.
  • Further investigation into quercetin's mechanisms of action may facilitate the development of novel, effective glioma therapies.
Keywords:
Gliomaapoptosismetastasismolecular mechanismpathologyquercetin

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