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Experimental Pythium aphanidermatum Infection in Rabbits.

Cristina G Zambrano1, Caroline Q Braga1, Vanessa Dal Ben1

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Pythium aphanidermatum, a plant pathogen, can experimentally infect rabbits, causing nodular lesions and an immune response. This study marks the first mammal infection report, suggesting adaptation to vertebrate hosts.

Keywords:
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Area of Science:

  • Veterinary Pathology
  • Oomycete Pathogenesis
  • Mammalian Infection Models

Background:

  • Pythium aphanidermatum is a known plant pathogen.
  • There are reports of Pythium aphanidermatum causing human infections.
  • The oomycete's ability to infect mammals remained unexplored.

Purpose of the Study:

  • To investigate the potential of Pythium aphanidermatum to infect domestic rabbits.
  • To characterize the pathological effects of Pythium aphanidermatum in a mammalian model.
  • To assess the host immune response to experimental Pythium aphanidermatum infection.

Main Methods:

  • Four domestic rabbits were subcutaneously inoculated with Pythium aphanidermatum.
  • Animals were monitored for 30 days post-inoculation.
  • Blood and tissue samples were collected for analysis, including histopathology and serology.

Main Results:

  • Inoculated rabbits developed palpable nodules within 5-10 days.
  • Necropsy revealed caseous nodular lesions with pyogranulomatous inflammation and oomycete hyphae.
  • Pythium aphanidermatum was re-isolated from lesions, and anti-Pythium aphanidermatum antibodies were detected.

Conclusions:

  • This study provides the first report of experimental Pythium aphanidermatum infection in a mammal.
  • Pythium aphanidermatum can establish infection at the inoculation site and elicit a host immune response in rabbits.
  • The findings suggest Pythium aphanidermatum may be adapting to vertebrate hosts.