Phage Revolution Against Multidrug-Resistant Clinical Pathogens in Southeast Asia

Area of Science:

• Microbiology
• Infectious Diseases
• Biotechnology

Background:

• Southeast Asia is a global hotspot for antimicrobial resistance (AMR).
• Emergence of multidrug-resistant (MDR) pathogens necessitates urgent therapeutic alternatives.
• Phage therapy, using bacteriophages to target bacteria, is a key prospect.

Purpose of the Study:

• To review current understanding of phages and strategies for phage therapy in Southeast Asia (SEA).
• To define a 'phage revolution' for treating MDR infections in the SEA context.
• To propose a three-phase strategy for implementing phage therapy in SEA.

Main Methods:

• Narrative review of existing literature on phages and AMR in SEA.
• Definition and conceptualization of a 'phage revolution'.
• Development of a phased strategy for clinical implementation.

Main Results:

• Identified critical need for phage therapy against MDR pathogens in SEA.
• Proposed a three-phase strategy: (1) enhance phage discovery/characterization, (2) establish lab protocols/clinical guidelines, (3) adapt regulatory standards.
• Highlighted the importance of regional scientific and regulatory considerations.

Conclusions:

• Phage therapy holds significant potential to combat AMR in SEA.
• A structured, phased approach is crucial for successful implementation.
• This review aims to stimulate discussion and advance phage therapy adoption in the region and globally.