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Related Experiment Videos

Renal allografts: evaluation by MR imaging.

H Hricak, F Terrier, B E Demas

    Radiology
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Magnetic resonance (MR) imaging effectively assesses renal transplants. Decreased corticomedullary contrast on MR images reliably indicates acute renal allograft rejection, distinguishing it from other complications.

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    Area of Science:

    • Radiology
    • Nephrology
    • Transplant Surgery

    Background:

    • Renal transplantation is a critical treatment for end-stage renal disease.
    • Accurate and timely assessment of renal allograft function and complications is essential for patient outcomes.
    • Magnetic resonance (MR) imaging offers non-invasive visualization of soft tissues, potentially valuable for transplant evaluation.

    Purpose of the Study:

    • To prospectively evaluate the diagnostic utility of MR imaging in assessing various complications of renal allografts.
    • To identify specific MR imaging features indicative of acute rejection, cyclosporine nephrotoxicity, and fluid collections.

    Main Methods:

    • Prospective study involving 45 patients with 46 renal allografts, resulting in 50 diagnoses from 50 imaging examinations.

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  • MR imaging was performed, focusing on T1-weighted images to assess corticomedullary contrast (CMC).
  • Diagnoses were confirmed and correlated with MR imaging findings, including normal function, acute tubular necrosis (ATN), acute and chronic rejection, cyclosporine nephrotoxicity, inflammation, and fluid collections.

    • Main Results:

    • Normal functioning allografts showed preserved CMC on T1-weighted images.
    • Decreased or absent CMC on T1-weighted images was the most consistent sign of acute renal allograft rejection (27/29 cases).
    • MR imaging differentiated perirenal fluid collections, including abscesses and hematomas, from seromas, lymphoceles, and urinomas based on signal intensity.

    Conclusions:

    • MR imaging, particularly T1-weighted sequences assessing CMC, is a valuable tool for diagnosing acute renal allograft rejection.
    • MR imaging can effectively identify and characterize perirenal fluid collections, aiding in management decisions.
    • MR imaging showed no abnormalities in allografts with cyclosporine nephrotoxicity in this study.