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The association between serum 25-hydroxyvitamin D concentrations and serum lipids in the Southern Thai population
Nutjaree Jeenduang1,2, Boonnisa Sangkaew1
1School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand.
Insights
Vitamin D sufficiency is linked to healthier lipid profiles, specifically lower triglycerides and higher HDL cholesterol in Southern Thai women. This suggests vitamin D may protect against cardiovascular disease risks in this population.
Area of Science:
- Endocrinology
- Cardiovascular Health
- Nutritional Science
Background:
- Dyslipidemia is a primary risk factor for cardiovascular diseases (CVD).
- Vitamin D deficiency is increasingly associated with CVD, but its relationship with serum lipids remains inconsistent.
- Investigating vitamin D's role in lipid metabolism is crucial for CVD prevention strategies.
Purpose of the Study:
- To examine the association between vitamin D status and serum lipid profiles in a Southern Thai population.
- To determine if vitamin D levels correlate with specific lipid parameters and dyslipidemia.
Main Methods:
- A cross-sectional study involving 726 healthy Southern Thai subjects.
- Measurement of serum 25-hydroxyvitamin D (25(OH)D), comprehensive lipid profiles, and anthropometric data.
- Statistical analyses included partial correlation, multiple linear regression, and multivariate logistic regression to assess relationships.
Main Results:
- Serum 25(OH)D levels showed negative correlations with BMI, total cholesterol, triglycerides, LDL-C, and body composition in women.
- Total cholesterol and BMI were identified as independent predictors of 25(OH)D levels in women.
- Vitamin D sufficiency was associated with significantly lower odds of hypertriglyceridemia and reduced HDL-C in women compared to those with vitamin D deficiency.
Conclusions:
- Vitamin D sufficiency may play a protective role against dyslipidemia, specifically hypertriglyceridemia and low HDL-C, in Southern Thai women.
- These findings suggest that maintaining adequate vitamin D levels could contribute to reduced cardiovascular disease risk in this demographic.
- Further research into vitamin D supplementation for lipid management and CVD prevention is warranted.
Introduction:
Dyslipidaemia is a major risk factor for cardiovascular diseases (CVD). Vitamin D deficiency has been found to be associated with CVD. However, the relationships between vitamin D and lipids are inconsistent. The aim of this study was to investigate the relationship between vitamin D status and serum lipids in Southern Thai subjects.
Material And Methods:
A total of 726 healthy subjects in Southern Thailand were enrolled in the study. Serum 25-hydroxyvitamin D (25(OH)D), lipid profiles, fasting plasma glucose, anthropometric data, blood pressure, and body composition were measured. The relationship between serum 25(OH)D levels and biochemical data was evaluated by partial correlation and multiple linear regression analyses. The association of serum 25(OH)D levels with dyslipidaemia was analysed using multivariate regression analysis.
Results:
Serum 25(OH)D levels were negatively correlated with body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and body composition parameters after adjusting for age in women. Multiple linear regression analysis showed that TC and BMI were independent predictors for 25(OH)D concentrations in women. Multivariate logistic regression analysis showed that the odds ratio of hypertriglyceridaemia (OR = 0.51; 95% CI: 0.32-0.80, p = 0.004) and reduced high-density lipoprotein cholesterol (HDL-C) (OR = 0.43; 95% CI: 0.26-0.71, p = 0.001) were significantly lower in vitamin D sufficiency when compared with hypovitaminosis D in women.
Conclusions:
Vitamin D sufficiency could reduce risk of hypertriglyceridaemia and reduced HDL-C, particularly in women, suggesting that vitamin D sufficiency may have beneficial effects on lipids and a decreased risk for CVD in Thai women.
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