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Associations between the lipid profile and the development of hypertension in young individuals - the preliminary
Piotr Chruściel1,2, Paulina Stemplewska1, Adam Stemplewski1
1Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.
Insights
Hypertension risk is linked to high-density lipoprotein (HDL) levels and specific HDL subfractions. Increased systolic blood pressure correlates with total HDL and HDL-3 subfraction concentrations, suggesting a tendency toward hypertension.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Hypertension Research
Background:
- Hypertension is a leading cause of global mortality and a major risk factor for cardiovascular disease (CVD).
- Elevated blood pressure (BP) frequently coexists with lipid disorders, further increasing cardiovascular risk.
- Specific subfractions of low-density lipoproteins (LDL) and high-density lipoproteins (HDL) are increasingly recognized as contributing to CV event risk.
Purpose of the Study:
- To investigate the associations between alterations in lipoprotein subfractions and the risk of developing hypertension.
- To explore the relationship between specific HDL subfractions and blood pressure levels in young adults.
Main Methods:
- A 2-year longitudinal study involving 200 volunteers aged 19-32 with normal blood pressure.
- Comprehensive assessments included medical examinations, electrocardiograms, echocardiograms, and lipid subfraction analysis using Lipoprint®.
- Two 24-hour ambulatory blood pressure monitoring sessions were conducted for each participant.
Main Results:
- Increased systolic blood pressure showed significant correlations with total HDL cholesterol concentrations (p = 0.0078), intermediate HDL subfractions (p = 0.0451), the HDL-3 subfraction (p = 0.0229), and intermediate density lipoprotein-A (IDL-A) (p = 0.038).
- A significant correlation was observed between increased diastolic blood pressure and overall HDL lipoprotein levels (p = 0.0454).
- The most abundant LDL subfractions were LDL 1-3, with LDL 4-5 being marginal and LDL 6-7 absent; HDL 4-6 were most abundant, with HDL 1-3 and HDL 8-10 present in lower concentrations.
Conclusions:
- The study indicates a correlation between total HDL levels and the HDL-3 subfraction concentration with systolic blood pressure.
- These findings suggest a potential link between specific HDL subfractions and the tendency to develop hypertension.
- Further research into lipoprotein subfractions may offer novel insights into hypertension risk stratification and management.
Introduction:
Hypertension is the leading direct cause of death in the world and one of the most important risk factors for cardiovascular disease (CVD). Elevated blood pressure (BP) often coexists with lipid disorders and is an additional factor that increases CV risk. Nowadays, we are able to distinguish low density lipoproteins (LDL) and high density lipoproteins (HDL) subfractions. Except LDL also HDL small subfractions can increase the risk of CV events. Therefore, we aimed to investigate the associations between changes of lipoprotein subfractions and the risk of hypertension development.
Material And Methods:
In 2-year long study 200 volunteers with normal blood pressure at the age of 19-32 years were included. Each volunteer underwent detailed medical examination, 12-lead electrocardiogram was taken at rest, echocardiogram, lipid subfraction assessment (using Lipoprint®) and two 24-hour BP measurements.
Results:
Mean total cholesterol concentration was 189 mg/dl (4.89 mmol/l), with mean LDL concentration of 107 mg/dl (2.77 mmol/l), HDL of 63 mg/dl (1.63 mmo/l), very low-density lipoprotein (VLDL) of 40 mg/dl (1.04 mmol/l) and triglycerides (TG) of 89 mg/dl (1.00 mmol/l). Subfractions LDL 1-3 were most abundant, LDL 4-5 making up a marginal portion and LDL 6-7 were not observed. Whereas, subfractions HDL 4-6 were most abundant, in lower concentration was present HDL 1-3 and HDL 8-10. We showed that increased systolic blood pressure coreclated significantly with HDL cholesterol concentrations (p = 0.0078), HDL intermediate subgractions (p = 0.0451), with HDL-3 subfraction (p = 0.0229), and intermediate density lipoprotein-A (IDL-A) (p = 0.038). A significant correlation between increased diastolic blood pressure and HDL lipoprotein levels (p = 0.0454) was only observed.
Conclusions:
Obtained results indicating correlation between total HDL levels and HDL-3 subfraction concentration (for systolic BP) and the tendency to develop hypertension.
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