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The influence of gestational hypertension on cord blood adiponectin levels: a case-controlled study
Justyna Czubilińska-Łada1, Aleksandra Gliwińska2, Elżbieta Świȩtochowska3
1Department of Neonatal Intensive Care, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, Poland.
Insights
Gestational hypertension did not affect cord blood adiponectin levels in newborns. Adiponectin levels did not correlate with most neonatal anthropometric measurements, except head circumference in the control group.
Area of Science:
- Perinatal medicine
- Neonatal development
- Endocrinology
Background:
- Gestational hypertension is a common pregnancy complication linked to metabolic disorders.
- Adiponectin, an adipocyte protein, has insulin-sensitizing and vascular-protective roles, but its neonatal impact is unclear.
- Understanding adiponectin's role in neonates born to mothers with gestational hypertension is crucial.
Purpose of the Study:
- To determine if gestational hypertension lowers cord blood adiponectin levels.
- To evaluate the correlation between cord blood adiponectin and neonatal anthropometric parameters.
Main Methods:
- A case-control study involving 89 newborns (30 from mothers with gestational hypertension, 59 healthy controls).
- Adiponectin levels were measured in cord blood.
- Neonatal anthropometric measurements and perinatal data were collected.
Main Results:
- No significant difference in cord blood adiponectin levels was found between newborns of mothers with and without gestational hypertension.
- Adiponectin levels did not correlate significantly with gestational age, body weight, length, or chest circumference.
- A significant correlation was observed between adiponectin levels and head circumference in the control group and overall.
Conclusions:
- Gestational hypertension does not significantly influence cord blood adiponectin levels.
- Cord blood adiponectin levels show limited correlation with neonatal anthropometric measurements in this cohort.
Introduction:
Gestational hypertension is one of the most common complications of pregnancy and childbirth worldwide and may be associated with metabolic disorders. Adiponectin is an adipocyte-specific plasma protein with insulin-sensitizing, vascular-protective, anti-inflammatory properties, and its role in metabolic disorders in prenatal and postnatal development in neonates remains unclear. The primary purpose of this study was to determine whether gestational hypertension is a condition lowering cord blood adiponectin level. Next, we have evaluated whether cord blood adiponectin level correlates with selected anthropometric parameters in neonates.
Material And Methods:
The case-control study included 89 newborns divided into two groups: 30 neonates in the study group whose mothers were diagnosed with gestational hypertension and 59 healthy neonates born from normotensive pregnancies. Adiponectin determinations were performed in both groups, and neonatal anthropometric measurements and perinatal data were collected.
Results:
There was no statistically significant difference (p = 0.27) between adiponectin concentration in cord blood of newborns from the study group [median (Q1-Q3) 9.86 μg/ml (8.16-13.26 μg/ml)] compared with the control group [median (Q1-Q3) 10.65 μg/ml (8.69-14.29 μg/ml)]. No statistically significant correlations were observed between adiponectin level and gestational age, body weight, body length, and chest circumference. A significant correlation was observed between adiponectin level and head circumference among newborns in the control group and among the entire population of newborns included in the study.
Conclusion:
No significant influence of gestational hypertension on cord blood adiponectin levels or their correlation with neonatal anthropometric measurements was observed.
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