Radiation Therapy for Malignant Lumbosacral Plexopathy: A Case Series

Area of Science:

• Oncology
• Radiation Oncology
• Pain Management

Background:

• Malignant lumbosacral plexopathy arises from direct extension of intrapelvic malignancies.
• This condition significantly impacts patient quality of life due to severe pain.

Purpose of the Study:

• To evaluate the efficacy of radiotherapy in managing pain associated with malignant lumbosacral plexopathy.
• To assess treatment outcomes and toxicities in patients receiving radiation therapy for this condition.

Main Methods:

• Retrospective review of medical records for patients treated between 2017 and 2020.
• Pain assessment using a numeric rating scale (0-10) before and after radiotherapy.
• Analysis of tumor invasion sites (iliopsoas, piriformis) and follow-up duration.

Main Results:

• All 11 patients (12 tumor sites) achieved pain relief post-radiotherapy.
• Nine patients experienced complete pain resolution, with maximum effect observed at a mean of 3 weeks.
• Low-grade toxicities (diarrhea, frequent urination) were reported; two patients had pain relapse.

Conclusions:

• Radiotherapy is a highly effective therapeutic option for malignant lumbosacral syndrome, providing significant pain relief.
• Early recognition and diagnosis are crucial for timely intervention.
• Patients should be offered all available therapeutic options, including palliative radiotherapy.