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Outcome of Treatment in Children With Chronic Viral Hepatitis C: A Single Centre Study

Amima Usman1, Iqtadar Seerat1, Sana Batool Rizvi1

  • 1Pediatric Gastroenterology and Hepatology, Pakistan Kidney and Liver Institute and Research Centre, Lahore, PAK.

Cureus
|February 14, 2022
PubMed

Insights

Pediatric chronic hepatitis C (HCV) treatment with pegylated interferon-alfa-2b (Peg-IFN-α-2b) and ribavirin, or sofosbuvir and ribavirin, achieved high sustained viral response (SVR) rates in children.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology
  • Virology

Background:

  • Chronic hepatitis C virus (HCV) infection affects children globally.
  • Effective treatment options for pediatric HCV genotypes 1 and 3 are crucial.
  • Sustained viral response (SVR) is the primary endpoint for successful HCV treatment.

Purpose of the Study:

  • To evaluate the efficacy of two combination therapies for chronic HCV in children.
  • To compare SVR rates in children with HCV genotypes 1 and 3.

Main Methods:

  • A retrospective study of 30 children under 15 years old treated for chronic HCV.
  • Patients received either pegylated interferon-alfa-2b (Peg-IFN-α-2b) plus ribavirin (for genotype 1) or sofosbuvir plus ribavirin (for genotype 3).
  • Treatment duration was 24 weeks, with SVR assessed 24 weeks post-treatment.

Main Results:

  • Overall, 90% (27/30) of children achieved SVR.
  • Children with genotype 1 (n=4) had a 100% SVR rate.
  • Children with genotype 3 (n=26) had an 88.4% SVR rate.

Conclusions:

  • Combined therapy with sofosbuvir and ribavirin or Peg-IFN-α-2b and ribavirin is highly effective in treating chronic HCV in children.
  • These regimens demonstrate excellent SVR rates across different HCV genotypes in pediatric populations.
  • The study supports the use of these combination therapies for pediatric HCV management.

Keywords:
genotypehepatitis-c infectioninterferon-alphasustained viral responsetreatment

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