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Updated: Oct 3, 2025

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Light-Emitting Diode Laser Therapy for Hyperoxia-Induced Retinal Abnormalities.

Maha Sabry Abd Eldaiem1, Salwa Abdelkawi Ahmed2, Aziza Abdelmonem Elsaeid1

  • 1Physics Department, Faculty of Science, Al Azhar University (Girls), Cairo, Egypt.

Journal of Lasers in Medical Sciences
|February 14, 2022
PubMed
Summary

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Low-level laser therapy effectively mitigates retinal damage caused by hyperoxia. This treatment improves retinal structure and oxidative balance, offering a potential therapeutic approach for hyperoxia-induced eye injuries.

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Cell Biology

Background:

  • Hyperoxygenation can lead to retinal tissue damage through oxidative stress and apoptosis.
  • Reactive oxygen species (ROS) play a key role in hyperoxia-induced cellular injury.

Purpose of the Study:

  • To investigate the protective effects of low-level laser therapy (LLLT) on retinal damage induced by acute hyperoxia in an animal model.
  • To evaluate biochemical and histological changes in the retina following hyperoxia and LLLT.

Main Methods:

  • Wistar albino rats were exposed to 90% oxygen for up to two weeks.
  • One subgroup received 670 nm light-emitting diode laser treatment.
  • Retinal tissues were analyzed for protein content, SDS-PAGE, total antioxidant capacity (TAC), hydrogen peroxide (H2O2), malondialdehyde (MDA), and histology.
Keywords:
Histological examinationHyperoxiaLight-emitting diode laser therapyOxidative stressRetinal protein

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Main Results:

  • Two weeks of hyperoxia increased retinal protein content, decreased TAC, and elevated H2O2 and MDA levels.
  • Histological analysis showed photoreceptor fragmentation and neovascularization in hyperoxia-exposed retinas.
  • LLLT treatment significantly improved retinal protein content, oxidative status, and histological structure.

Conclusions:

  • Light-emitting diode laser therapy demonstrates efficacy in reducing hyperoxia-induced retinal damage.
  • LLLT presents a promising therapeutic strategy for managing oxidative stress-related retinal conditions.