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Related Experiment Videos

Tenoxicam in soft-tissue rheumatism.

D Schorn

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |March 1, 1986
    PubMed
    Summary

    Tenoxicam effectively reduced pain and improved function in patients with inflammatory conditions. Both 10 mg/d and 20 mg/d dosages showed similar efficacy and good tolerability over a 2-week trial.

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    Area of Science:

    • Pharmacology
    • Rheumatology
    • Clinical Trials

    Background:

    • Extra-articular inflammatory conditions present a significant challenge in patient management.
    • Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for symptom relief.
    • Tenoxicam is an NSAID with demonstrated anti-inflammatory and analgesic properties.

    Purpose of the Study:

    • To evaluate the efficacy and tolerability of tenoxicam in patients with extra-articular inflammatory conditions.
    • To compare the effects of two different dosages of tenoxicam (10 mg/d and 20 mg/d) against a placebo.
    • To assess the impact of tenoxicam on key parameters such as tenderness, pain, and functional limitation.

    Main Methods:

    • A randomized, double-blind, placebo-controlled trial was conducted.
    • Ninety patients diagnosed with various extra-articular inflammatory conditions participated.
    • Treatment duration was two weeks, with participants receiving either tenoxicam (10 mg/d or 20 mg/d) or a placebo.

    Main Results:

    • Tenoxicam demonstrated statistically significant improvements in all assessed parameters for patients with moderate to severe baseline symptoms.
    • Improvements were noted in tenderness, pain during mobility, and functional limitations.
    • No significant difference in efficacy was observed between the 10 mg/d and 20 mg/d tenoxicam dosages.
    • Tenoxicam was generally well-tolerated across both dosage groups, with only mild adverse reactions reported, similar to the placebo group.

    Conclusions:

    • Tenoxicam is an effective treatment for extra-articular inflammatory conditions, offering significant relief from pain and functional impairment.
    • Both 10 mg/d and 20 mg/d dosages of tenoxicam provide comparable therapeutic benefits.
    • The drug exhibits a favorable safety profile, with mild adverse events comparable to placebo, supporting its use in clinical practice.

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