Related Experiment Video
Updated: Oct 3, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Perinatal Opioid Use Disorder Research, Race, and Racism: A Scoping Review
Davida M Schiff1, Erin C Work1, Bridget Foley2
1Division of General Academic Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts.
Insights
Racial and ethnic disparities persist in maternal-infant health and opioid use disorder (OUD) treatment. This review found poor reporting of race/ethnicity data, hindering efforts to achieve health equity for affected dyads.
Area of Science:
- Perinatal Health
- Health Equity Research
- Substance Use Disorders
Background:
- Racial and ethnic inequities are prevalent in maternal-infant health and substance use disorder treatment.
- Opioid use disorder (OUD) in pregnant individuals and its impact on infants present significant public health challenges.
- Understanding disparities in care and outcomes is crucial for addressing these inequities.
Purpose of the Study:
- To systematically review research on maternal-infant dyads affected by OUD.
- To evaluate racial/ethnic disparities in health utilization and outcomes.
- To critically assess the reporting and inclusion of race/ethnicity data in OUD research.
Main Methods:
- Systematic review of peer-reviewed literature from MEDLINE, Embase, and Web of Science (2000-2020).
- Included studies reporting health utilization and outcomes for dyads affected by OUD from pregnancy through the infant's first birthday.
- Extracted data on race/ethnicity, study exposures/outcomes, data analysis, and discussion of findings related to race/ethnicity and racism.
Main Results:
- Of 2023 articles reviewed, 152 quantitative and 17 qualitative studies were included.
- Few studies (3/152 quantitative) explicitly evaluated racial/ethnic differences among dyads.
- Race/ethnicity data were poorly reported; many studies mentioned race/ethnicity but few analyzed or adjusted for it, and none discussed racism's role.
Conclusions:
- Few studies are designed to evaluate racial/ethnic inequities in perinatal OUD.
- Inadequate reporting and analysis of race/ethnicity data impede understanding of disparities.
- Prioritizing inclusion of marginalized groups and addressing structural racism is essential for achieving health equity in perinatal OUD care.
Context:
Racial/ethnic inequities are well documented in both maternal-infant health and substance use disorder treatment outcomes.
Objective:
To systematically review research on maternal-infant dyads affected by opioid use disorder (OUD) to evaluate for racial/ethnic disparities in health utilization or outcomes and critically assess the reporting and inclusion of race/ethnicity data.
Data Sources:
Peer-reviewed literature in MEDLINE, Embase, and Web of Science from 2000 to 2020.
Study Selection:
Research reporting health utilization and outcomes data on dyads affected by OUD during pregnancy through the infant's first birthday.
Data Extraction:
We extracted data on race/ethnicity, study exposures/outcomes, how race/ethnicity data were analyzed, how authors discussed findings associated with race/ethnicity, and whether racism was mentioned as an explanation for findings.
Results:
Of 2023 articles reviewed, 152 quantitative and 17 qualitative studies were included. Among quantitative studies, 66% examined infant outcomes (n = 101). Three articles explicitly focused on evaluating racial/ethnic differences among dyads. Among quantitative studies, 112 mentioned race/ethnicity, 63 performed analyses assessing for differences between exposure groups, 27 identified racial/ethnic differences, 22 adjusted outcomes for race/ethnicity in multivariable analyses, and 11 presented adjusted models stratified by race/ethnicity. None of the qualitative studies addressed the role that race, ethnicity, or racism may have had on the presented themes.
Conclusions:
Few studies were designed to evaluate racial/ethnic inequities among maternal-infant dyads affected by OUD. Data on race/ethnicity have been poorly reported in this literature. To achieve health equity across perinatal OUD, researchers should prioritize the inclusion of marginalized groups to better address the role that structural racism plays.
Related Concept Videos
Stereotypes, Prejudice, and Discrimination
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Opioid Analgesics: Morphine and Other Natural Cogeners

