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Three-Dimensional Printing of Large-Scale, High-Resolution Bioceramics with Micronano Inner Porosity and Customized

Boqing Zhang, Xingyu Gui, Ping Song

  • 1Department of Orthopedics, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China.

ACS Applied Materials & Interfaces
|February 14, 2022
PubMed
Summary

Large-scale hydroxyapatite bioceramics were fabricated using digital light projection (DLP) printing, showing promising bone regeneration capabilities. This advancement enables the creation of precise, porous scaffolds for tissue engineering applications.

Keywords:
DLP technologybone regenerationlarge-scalemicronanosurface architectureosteoinduction

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Additive Manufacturing

Background:

  • Three-dimensional (3D) printing offers advanced manufacturing of complex bioceramics.
  • Digital Light Projection (DLP) printing achieves high resolution in small bioceramic parts.
  • Challenges remain in producing large-scale, high-precision bioactive ceramics.

Purpose of the Study:

  • To fabricate large-scale hydroxyapatite porous bioceramics using DLP.
  • To investigate the control of surface micro/nanoporous structures.
  • To evaluate the bone regeneration potential of the fabricated bioceramics.

Main Methods:

  • Fabrication of large-scale (>150 mm) hydroxyapatite bioceramic using DLP.
  • Control of micronanoporous surface structures (<65 μm resolution) via solid content and sintering.
  • In vitro and in vivo evaluation of bone regeneration ability.

Main Results:

  • Successfully produced large-scale hydroxyapatite porous bioceramics with controlled micronanoporous structures.
  • Demonstrated promising bone regeneration ability in both in vitro and in vivo studies.
  • Established DLP technology's capability for accurate porosity in large-scale scaffolds.

Conclusions:

  • DLP technology is suitable for producing large-scale, high-precision bone tissue engineering scaffolds.
  • The fabricated hydroxyapatite bioceramics show significant potential for bone regeneration.
  • Microenvironment control is crucial for bone tissue regeneration, supported by these findings.