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MCM3AP-AS1: A LncRNA Participating in the Tumorigenesis of Cancer Through Multiple Pathways

Bei Wang1, Jinlan Chen1, Chen Lin1

  • 1College of Medical Science, China Three Gorges University, Yichang 443002, China.

Mini Reviews in Medicinal Chemistry
|February 14, 2022
PubMed
Abstract

Insights

Long non-coding RNA MCM3AP-AS1 shows abnormal expression in tumors, impacting proliferation and invasion. MCM3AP-AS1 is a promising diagnostic marker and therapeutic target for various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Tumor development is linked to abnormal long non-coding RNA (LncRNA) expression.
  • MCM3AP-AS1 dysregulation affects cancer cell proliferation, invasion, and translocation.

Purpose of the Study:

  • To review the pathophysiological functions of MCM3AP-AS1 in various tumors.
  • To elucidate the molecular mechanisms of MCM3AP-AS1 in cancer development.

Main Methods:

  • Systematic review of published literature.
  • Analysis of PubMed-indexed studies on MCM3AP-AS1.

Main Results:

  • Abnormal MCM3AP-AS1 expression correlates with tumor proliferation, invasion, and migration.
  • MCM3AP-AS1 regulates target miRNA and protein expression via signaling pathways.

Conclusions:

  • LncRNA MCM3AP-AS1 is a viable tumor marker.
  • MCM3AP-AS1 presents potential as a therapeutic target for multiple cancers.
Keywords:
Long non-coding RNAMCM3AP-AS1biomarkerscancerprognosistreatment

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