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Osthole: Synthesis, Structural Modifications, and Biological Properties.

Zili Ren1, Min Lv1, Hui Xu1

  • 1College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China.

Mini Reviews in Medicinal Chemistry
|February 14, 2022
PubMed
Summary
This summary is machine-generated.

Osthole, a natural compound from Cnidium monnieri, shows diverse biological activities. This review details its synthesis, modifications, bioactivities, and structure-activity relationships for potential drug and pesticide development.

Keywords:
Ostholebiological activitymechanisms of actionstructural modificationstructure-activity relationshiptotal synthesis

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Osthole is a coumarin derivative from Cnidium monnieri (L.), a traditional Chinese medicine.
  • It possesses a wide spectrum of biological properties.
  • Recent research has focused on its therapeutic and agricultural potential.

Purpose of the Study:

  • To review the total synthesis and structural modifications of osthole and its analogs.
  • To outline the progress in bioactivities of osthole and its derivatives since 2016.
  • To discuss structure-activity relationships and mechanisms of action for future applications.

Main Methods:

  • Literature review of studies on osthole synthesis and bioactivity.
  • Analysis of structural modifications and their impact on activity.
  • Synthesis of structure-activity relationship (SAR) data.

Main Results:

  • Comprehensive overview of osthole's total synthesis and analog development.
  • Updated summary of osthole's biological activities and therapeutic potential.
  • Detailed discussion on SAR and mechanisms of action.

Conclusions:

  • Osthole and its analogs hold significant promise for drug discovery and pesticide development.
  • Understanding SAR and mechanisms is crucial for optimizing osthole derivatives.
  • Further research can accelerate the application of osthole in medicine and agriculture.