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Post-Menopausal Status and Risk for Cervical Dysplasia
Kenia Edwards1, Mary Fatehi1, Joshua Fogel1,2
1Department of Obstetrics and Gynecology, Nassau University Medical Center, East Meadow, New York, USA.
The Gulf Journal of Oncology
|February 14, 2022
Summary
Post-menopausal status did not significantly correlate with abnormal Pap smears or cervical dysplasia. However, high-grade dysplasia strongly associated with high-grade Pap smear results, supporting continued screening for all women.
Area of Science:
- Gynecology
- Oncology
- Cervical Cancer Screening
Background:
- Cervical cancer screening guidelines recommend Pap smears and colposcopy.
- The role of menopausal status in cervical dysplasia detection requires clarification.
Purpose of the Study:
- To determine the association between post-menopausal status and abnormal Pap smear cytology.
- To investigate the link between post-menopausal status and cervical dysplasia detected by colposcopy-directed biopsy.
- To examine the association of biopsy-confirmed dysplasia with Pap smear results.
Main Methods:
- Retrospective study of 480 women with abnormal Pap smears referred for colposcopy.
- Analysis of demographic, sexual activity, and disease-related covariates.
- Evaluation of post-menopausal status in relation to cervical cytology and dysplasia.
Main Results:
- Post-menopausal status showed no significant association with abnormal Pap smears or cervical dysplasia.
- A significant association was found between high-grade dysplasia and high-grade Pap smear results (ASC-H, HSIL, AGC).
Conclusions:
- Current cervical cancer screening guidelines should be maintained for all women, irrespective of menopausal status.
- While post-menopausal status may not necessitate biopsy, continued screening is recommended.
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