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Updated: Oct 3, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Promoted Aerobic Oxyphosphorylation of α-Diazoesters with H-Phosphine Oxides
Hongyan Zhou1,2, Ganggang Wang2, Cunhui Wang2
1College of Science, Gansu Agricultural University, Lanzhou 730070, China.
Abstract:
A visible-light-promoted aerobic oxyphosphorylation of α-diazoesters and H-phosphine oxides has been developed. Using air as the oxygen source, the reaction proceeded smoothly at room temperature under blue-light irradiation. The α-diazoesters, molecular oxygen, and H-phosphine oxides are conveniently incorporated into a C-O-P(O) unit in one step. The preliminary mechanistic studies indicated that a light-triggered radical process is involved. The developed strategy shows the unrevealed reactivity of diazo compounds with H-phosphine oxides and has potential value in synthetic applications.
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