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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Oct 3, 2025

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
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Choroidal Caverns in Stargardt Disease.

Dario Pasquale Mucciolo1,2, Dario Giorgio1, Myrta Lippera1

  • 1Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.

Investigative Ophthalmology & Visual Science
|February 14, 2022
PubMed
Summary
This summary is machine-generated.

Choroidal caverns are associated with advanced recessive Stargardt disease (STGD1). This finding may indicate a degenerative origin in later stages of STGD1.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Retinal Degeneration

Background:

  • Recessive Stargardt disease (STGD1) is a leading genetic cause of macular degeneration.
  • Understanding STGD1's clinical manifestations is crucial for patient management.

Purpose of the Study:

  • To identify and characterize choroidal caverns in patients with STGD1.
  • To investigate the clinical features associated with choroidal caverns in STGD1.

Main Methods:

  • Retrospective analysis of 86 STGD1 patients.
  • Ophthalmic examinations included visual acuity, fundus photography, autofluorescence, OCT, and OCT angiography.

Main Results:

  • Choroidal caverns were found in 13.3% of eyes (21 patients).
  • These caverns appeared exclusively in advanced STGD1 (stages III and IV).
  • Patients with caverns showed larger macular atrophy, worse visual acuity, and thinner choroids.

Conclusions:

  • Choroidal caverns are a sign of advanced STGD1.
  • A degenerative etiology for choroidal caverns in STGD1 is proposed.