Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Argyria: microanalytic-morphologic correlation using paraffin-embedded tissue.

S Landas, S M Bonsib, R Ellerbroek

    Ultrastructural Pathology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tilorone-induced lysosomal storage of glycosaminoglycans in cultured corneal fibroblasts: biochemical and physicochemical investigations.

    The Biochemical journal·1995
    Same author

    [Traumatic injury of the internal carotid artery in the extracranial segment. Description of a severe late complication].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·1995
    Same author

    Identification of the valine 408 to methionine mutation in the LDL receptor in a Greek patient with homozygous familial hypercholesterolemia.

    Clinical genetics·1995
    Same author

    [Possible applications of ultrasound in corticotomy-callus distraction].

    Aktuelle Radiologie·1995
    Same author

    Estrogen replacement therapy and the risk of thromboembolism.

    South Dakota journal of medicine·1995
    Same author

    PAs committed to practice with physician supervision.

    Texas medicine·1995
    Same journal

    Autism spectrum disorder (ASD): zinc suppresses cerebellar ultrastructural alterations and modulates the oxidative stress/gliosis/neuronal loss axis-mediated ASD.

    Ultrastructural pathology·2026
    Same journal

    Alteration of adult neural stem cells by gold nanoparticles in a demyelination model induced in the hippocampus of adult male mice: a structural and ultrastructural study.

    Ultrastructural pathology·2026
    Same journal

    The potential neuroprotective effect of apigenin on cerebellar cortex alterations in valproic acid-induced autism model of male albino rat pups: a histological and immunohistochemical study.

    Ultrastructural pathology·2026
    Same journal

    Deposits of C3 glomerulopathies have ultrastructural hints to correlate with immunofluorescent findings.

    Ultrastructural pathology·2026
    Same journal

    Effect of concurrent administration of granulocyte colony stimulating factor and pirfenidone on experimentally induced lung fibrosis in adult male albino rats (a histological, immunohistochemical & ultrastructural study).

    Ultrastructural pathology·2026
    Same journal

    From lamellar and storage bodies to mitophagy: a comprehensive view of mitochondrial ultrastructure in differentiated SH-SY5Y cells.

    Ultrastructural pathology·2026
    See all related articles

    Scanning electron microscopy with x-ray microanalysis accurately identifies inorganic deposits in tissue. This method confirmed a case of argyria, proving useful for heavy element detection in tissue sections.

    Area of Science:

    • Materials Science
    • Pathology
    • Analytical Chemistry

    Background:

    • Scanning electron microscopy (SEM) equipped with energy dispersive spectroscopy (EDS) offers elemental analysis capabilities.
    • Accurate identification of inorganic deposits in biological tissues is crucial for diagnosing various conditions.

    Observation:

    • A case of florid argyria was investigated using sequential microscopic techniques.
    • The same deparaffinized tissue sections were examined by light microscopy, SEM, backscattered electron imaging, and EDS (x-ray microanalysis).

    Findings:

    • X-ray microanalysis precisely identified silver deposits, confirming the clinical diagnosis of argyria.
    • The combination of SEM and EDS provided detailed compositional information of the inorganic deposits.

    Related Experiment Videos

    Implications:

    • X-ray microanalysis of paraffin-embedded tissue is a valuable tool for identifying inorganic deposits.
    • This technique offers a simple, rapid, and cost-effective method for precise elemental analysis in histopathology.
    • The study highlights the utility of advanced microscopy in clinical diagnostics.