Mapping Pediatric Oncology Clinical Trial Collaborative Groups on the Global Stage

Area of Science:

• Pediatric Oncology
• Global Health
• Clinical Research Collaboration

Background:

• The global pediatric oncology landscape, especially in high-burden regions like Africa, Asia, and Central/South America, is under-documented.
• Understanding existing international pediatric cancer clinical trial groups is crucial for global research and data-sharing initiatives.

Purpose of the Study:

• To review the formation and research pursuits of international pediatric cancer clinical trial groups.
• To inform global collaborative research efforts aligned with the WHO Global Initiative for Childhood Cancer.

Main Methods:

• A narrative literature review was conducted on collaborative pediatric cancer clinical research groups across continents.
• An inventory of these groups was compiled and reviewed by regional and continental leaders.
• Common structural and research themes among consortia were identified.

Main Results:

• Significant variability exists in the structure, history, and objectives of international pediatric cancer clinical trial groups.
• Some regions feature established groups with adapted treatment regimens, while others focus on registry infrastructure via multinational support or partnerships.

Conclusions:

• A one-size-fits-all approach to international collaboration is ineffective due to varying local needs and resources.
• Needs assessments, grassroots approaches, twinning relationships, and implementation science are vital for successful global partnerships in pediatric cancer research.