Molecular physiology of iron trafficking in Drosophila melanogaster

Iron homeostasis in insects is less-well understood comparatively to mammals. The classic model organism Drosophila melanogaster has been recently employed to explore how iron is trafficked between and within cells. An outline for iron absorption, systemic delivery, and efflux is thus beginning to emerge. The proteins Malvolio, ZIP13, mitoferrin, ferritin, transferrin, and IRP-1A are key players in these processes. While many features are shared with those in mammals, some physiological differences may also exist. Notable remaining questions include the existence and identification of functional transferrin and ferritin receptors, and of an iron exporter like ferroportin, how systemic iron homeostasis is controlled, and the roles of different tissues in regulating iron physiology. By focusing on aspects of iron trafficking, this review updates on presently known complexities of iron homeostasis in Drosophila.