Stress-related dysautonomias and neurocardiology-based treatment approaches
Nil Z Gurel1, Joseph Hadaya2, Jeffrey L Ardell1
1UCLA Neurocardiology Research Program of Excellence, Los Angeles, CA, United States of America; UCLA Cardiac Arrhythmia Center, UCLA Health System, Los Angeles, CA, United States of America.
Insights
This review highlights the link between stress, the autonomic nervous system (dysautonomia), and heart disease. Autonomic modulation offers a promising complementary therapy for stress-related cardiovascular and psychiatric conditions.
Area of Science:
- Neurocardiology
- Psychiatry
- Epidemiology
Background:
- Bidirectional relationships exist between psychiatric disorders and heart disease.
- Impaired autonomic nervous system function (dysautonomia) plays a key role in these conditions.
- Research is translating experimental findings into clinical applications.
Purpose of the Study:
- To review current research on stress-related dysautonomias.
- To discuss novel treatment approaches for these conditions.
- To emphasize the impact of stress on the cardiac neuronal hierarchy.
Main Methods:
- Comprehensive review of state-of-the-art investigations.
- Analysis of novel treatment strategies for dysautonomias.
- Focus on the effects of stress on cardiac autonomic regulation.
Main Results:
- Autonomic modulation is an emerging therapeutic strategy for dysautonomias.
- This approach may complement existing pharmacological treatments.
- It has the potential to reduce side effects and address treatment resistance.
Conclusions:
- Autonomic modulation is a promising strategy for treating stress-related dysautonomias.
- Further research is needed to optimize treatment, usability, and address ethical concerns.
- This approach could significantly impact cardiovascular and psychiatric disorder management.
Abstract:
Cardiovascular and psychiatric disorders are among the most commonly treated conditions worldwide. Research in neurocardiology, psychiatry, and epidemiology have defined bidirectional relationships between psychiatric disorders and heart disease, affirming the role of impaired autonomic nervous system, or dysautonomia in the prognosis and development in these disorders. These studies have fueled rapid clinical translation of experimental findings, with potential to complement existing pharmacological therapies. In this review, we comprehensively discuss the state-of-the-art investigations and novel treatment approaches for stress-related dysautonomias, emphasizing the effects of stress on the cardiac neuronal hierarchy. Increasing evidence suggests that autonomic modulation stands as an attractive therapeutic strategy in the treatment of dysautonomias that could complement existing therapies and possibly reduce the burden of drug-related side effects and treatment-resistant conditions. Further investigations regarding treatment optimization, selectivity, usability, and ethical concerns are required.
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