Stress-related dysautonomias and neurocardiology-based treatment approaches

Nil Z Gurel1, Joseph Hadaya2, Jeffrey L Ardell1

  • 1UCLA Neurocardiology Research Program of Excellence, Los Angeles, CA, United States of America; UCLA Cardiac Arrhythmia Center, UCLA Health System, Los Angeles, CA, United States of America.

Insights

This review highlights the link between stress, the autonomic nervous system (dysautonomia), and heart disease. Autonomic modulation offers a promising complementary therapy for stress-related cardiovascular and psychiatric conditions.

Area of Science:

  • Neurocardiology
  • Psychiatry
  • Epidemiology

Background:

  • Bidirectional relationships exist between psychiatric disorders and heart disease.
  • Impaired autonomic nervous system function (dysautonomia) plays a key role in these conditions.
  • Research is translating experimental findings into clinical applications.

Purpose of the Study:

  • To review current research on stress-related dysautonomias.
  • To discuss novel treatment approaches for these conditions.
  • To emphasize the impact of stress on the cardiac neuronal hierarchy.

Main Methods:

  • Comprehensive review of state-of-the-art investigations.
  • Analysis of novel treatment strategies for dysautonomias.
  • Focus on the effects of stress on cardiac autonomic regulation.

Main Results:

  • Autonomic modulation is an emerging therapeutic strategy for dysautonomias.
  • This approach may complement existing pharmacological treatments.
  • It has the potential to reduce side effects and address treatment resistance.

Conclusions:

  • Autonomic modulation is a promising strategy for treating stress-related dysautonomias.
  • Further research is needed to optimize treatment, usability, and address ethical concerns.
  • This approach could significantly impact cardiovascular and psychiatric disorder management.

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