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Updated: Oct 3, 2025

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
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Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

Published on: March 14, 2021

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Overexpression of phosphatidylethanolamine-binding protein 4 (PEBP4) associates with recurrence of meningiomas

Ren-Qiang Huang1, Feng Chen2, Ying-Bo Jiang3

  • 1Department of Neurosurgery, The First Naval Hospital of Southern Theater Command, Zhanjiang 524005, China.

Clinical Neurology and Neurosurgery
|February 14, 2022
PubMed
Abstract

Insights

High phosphatidylethanolamine-binding protein 4 (PEBP4) expression correlates with increased meningioma grade and recurrence risk. PEBP4 may serve as a prognostic biomarker for meningioma patients.

Area of Science:

  • Neuro-oncology
  • Molecular Pathology
  • Cancer Biomarkers

Background:

  • Abnormal phosphatidylethanolamine-binding protein 4 (PEBP4) expression is linked to various cancers.
  • The role of PEBP4 in meningioma pathogenesis and prognosis is not well understood.

Purpose of the Study:

  • To investigate PEBP4 expression in meningioma tissues.
  • To determine the correlation between PEBP4 expression and clinical outcomes in meningioma patients.

Main Methods:

  • Immunohistochemical staining was used to evaluate PEBP4 and Ki-67 expression in 65 meningioma samples.
  • Statistical analyses, including Kruskal-Wallis and multivariate regression, were employed to assess correlations and prognostic value.

Main Results:

  • PEBP4 expression was significantly elevated in atypical and anaplastic meningiomas compared to classical types.
  • PEBP4 levels strongly correlated with Ki-67 expression, tumor grade, and clinical recurrence.
  • High PEBP4 expression was associated with longer recurrence-free survival.

Conclusions:

  • PEBP4 plays a role in meningioma progression and is linked to higher pathological grades.
  • PEBP4 expression is a potential prognostic biomarker for meningioma patients.
Keywords:
MeningiomaPhosphatidylethanolamine-binding protein 4PrognosisRecurrence

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