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Related Experiment Video

Updated: Oct 3, 2025

FIBS-enabled Noninvasive Metabolic Profiling

FIBS-enabled Noninvasive Metabolic Profiling

Published on: February 3, 2014

Biosensor-enabled pathway optimization in metabolic engineering.

Yuxi Teng¹, Jianli Zhang¹, Tian Jiang¹

¹School of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA 30602, USA.

Current Opinion in Biotechnology

|February 14, 2022

Summary

Genetically encoded biosensors enable dynamic regulation and strain screening for optimizing microbial production of valuable products from renewable resources. These tools address challenges in complex biological pathway optimization for enhanced industrial biotechnology.

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Area of Science:

Biotechnology and synthetic biology
Metabolic engineering
Microbial physiology

Background:

Microbes naturally convert renewable substrates into valuable metabolites via metabolic pathways.
Optimizing these pathways for maximum productivity is challenging due to complex biological systems.
Genetically encoded biosensors offer a solution for monitoring and regulating these pathways.

Purpose of the Study:

To review recent advancements in biosensor applications for microbial production.
To highlight the role of biosensors in dynamic pathway regulation and strain screening.
To discuss the potential of biosensors in enhancing the production of diverse desirable products.

Main Methods:

Review of literature on genetically encoded biosensors.
Analysis of biosensor-mediated dynamic regulation strategies.
Examination of biosensor applications in microbial strain screening for high-yield production.

Main Results:

Biosensors provide measurable outputs linked to metabolite concentrations or environmental changes.
Dynamic regulation using biosensors allows for real-time pathway optimization.
Biosensors facilitate high-throughput screening of microbial strains for improved production.

Conclusions:

Biosensor technology is crucial for overcoming limitations in microbial production optimization.
Advancements in biosensors enable more efficient and precise control of microbial metabolic pathways.
This review underscores the significant impact of biosensors on industrial biotechnology and sustainable chemical production.